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Last Updated May 3rd 2022, 12:41:16 am

Acemannan (ACE) is a polysaccharide (carbohydrate) located within the soft pulp of the inner leaves of Aloe plants. Many of the beneficial properties of Aloe have been attributed to the acemannan present in the gel.


Acemannan is a β(1,4)-acetylated mannan-based polysaccharide derived from the plant aloe vera (Barbadensis milleri).

Healing Properties

Acemannan has potential immunostimulant, antiviral, antineoplastic, and gastrointestinal properties.

Anti-Aphthous activity

Helps prevent/treat aphthous ulcers (small, shallow sores inside the mouth or at the base of the gums).[1]




Helps prevent, inhibit or halt the development of a neoplasm (a tumor).[3]

Bone Health

(Skeletal Health)


Promotes the functioning of osteogenesis (i.e. producing bone)

Bone Regeneration

Acemannan, a β-(1–4)-acetylated polymannose extracted from Aloe vera gel, has been proposed as biomaterial for bone regeneration.[3:1]

  • Acemannan is an effective bioactive agent for bone regeneration, enhancing bone growth as assayed in two- and three-dimensions.[3:2]
  • Treatment with Acemannan for calvarial (skullcap, or the upper part of the neurocranium which covers the cranial cavity containing the brain) defect healing showed a significant increase in bone surface and bone volume and tissue mineral density. The acemannan-treated groups also had a denser bone matrix.[3:3]

Gastrointestinal Health


Oral Health

Disease / Symptom Treatment


Acemannan is degraded by the intestinal microbiota to form oligosaccharides. These oligosaccharides inhibit intestinal glucose absorption.[4]

Glucose Regulation

Acemannan treatment promotes a significant reduction in blood glucose.[4:1]

Blood Pressure

Acemannan treatment promotes a significant reduction in blood pressure.[4:2]

Lipid Profile Regulation

Acemannan treatment promotes improvement of the lipid profile.[4:3]

Viral Infections


  1. Title: Medicinal plant and their bioactive phytochemicals in the treatment of recurrent aphthous ulcers: A review of clinical trials
    Publication: Pharmacognosy Reviews
    Date: May 2018
    Study Type: Human Study: Review of clinical trials
    Author(s): Fatemeh Heydarpour, Masoomeh Abasabadi, Zahra Shahpiri, Siavash Vaziri, Hesam Aldin Nazari, Fariba Najafi, Maryam Mirzaei, Mohammad Hosein Farzaei
    Institution(s): Kermanshah University of Medical Sciences, Kermanshah, Iran; Tehran University of Medical Sciences, Tehran, Iran; Tabriz University of Medical Science, Tabriz, Iran
    Copy: archive, archive-mirror ↩︎

  2. Title: Enhancement of allo-resposiveness of human lymphocytes by acemannan (CarrisynTM)
    Publication: International Journal of Immunopharmacology
    Date: March 1988
    Study Type: Human Study: In Vitro
    Author(s): Debra Womble, J. Harold Helderman
    Institution(s): The University of Texas Southwestern Medical Center at Dallas, USA
    Copy: archive, archive-mirror ↩︎

  3. Title: Acemannan increased bone surface, bone volume, and bone density in a calvarial defect model in skeletally-mature rats
    Publication: Journal of Dental Sciences
    Date: July 2018
    Study Type: Animal Study: In Vivo
    Author(s): Dyna Jeanne D. Godoya, Jaroenporn Chokboribal, Ruben Pauwels, Wijit Banlunara, Polkit Sangvanich, Sukanya Jaroenporn, Pasutha Thunyakitpisal
    Institutions: Chulalongkorn University, Bangkok, Thailand; Phranakhon Rajabhat University, Bangkok, Thailand; Biomedical Sciences Group, KU Leuven, Belgium
    Copy: archive, archive-mirror ↩︎ ↩︎ ↩︎ ↩︎

  4. Title: Compositional and Structural Features of the Main Bioactive Polysaccharides Present in the Aloe vera Plant
    Publication: Journal of AOAC International
    Date: November 2019
    Study Type: Review of Plant Composition
    Author(s): Minjares-Fuentes R, Femenia A, Comas-Serra F, Rodríguez-González VM
    Institution(s): Universidad Juárez del Estado de Durango, Durango, México; University of the Balearic Islands, Palma de Mallorca, Spain
    Copy: archive, archive-mirror ↩︎ ↩︎ ↩︎ ↩︎