- 1. Healing Properties
- 2. Disease / Symptom Treatment
- 2.1. Birth Defects
- 2.2. Cancer
- 2.3. Diabetes
- 2.4. Dysbiosis
- 2.5. Cardiovascular Disease
- 2.6. Neurodegenerative Diseases
- 3. Synergistic Effects
Resveratrol is a type of natural phenol produced by several plants.
Resveratrol mimics the antioxidant and antiaging effects of caloric restriction.
Resveratrol inhibits the growth of human gastric carcinoma cells.
blocks cancer blood vessel growth.
Resveratrol may prevent neuronal death, stop amyloid deposition, and promote blood brain barrier inegrity.
Resveratrol treatment has been shown to preserve the integrity of the blood-brain barrier (BBB) in Alzheimer’s Disease (AD) patients. Resveratrol also induced adaptive immune responses that promoted brain resilience to amyloid deposition. Resveratrol may slow cognitive decline in AD, and may arrest neuronal death. Resveratrol may seal off a leaky blood brain barrier and contribute to cognitive and functional improvement.[3:1]
Resveratrol has been shown to improve biomarkers related to vascular functions.
The vascular-related effects of resveratrol include:
- Suppression of platelet aggregation
- Inhibition of low-density lipoprotein oxidation
- Activation of endothelial nitric oxide synthase (eNOS)
- Inhibition of leukocyte adhesion
- Inhibition of tissue factor expression
- Reduction in vascular cell adhesion molecule-1 expression.
Resveratrol improves vessel responsiveness (especially when taken in conjunction with 40 mins of regular daily exercise).[4:1]
Resveratrol promotes endothelium-independent relaxation of thoracic aorta.[4:2]
Gut Health (Digestive Health)
Helps modulate gut microbiota.
- Promotes neuroprotection in the myenteric plexus (myenteric plexus is the major nerve supply to the gastrointestinal tract and controls GI tract motility).
- Antioxidant effect in the intestinal wall.[6:1]
Resveratrol and regular aerobic exercise improves vascular functions and biomarkers related to vessel responsiveness.[4:3]
Reduces renal oxidative stress.
Beverages Rich in Resveratrol and Physical Activity Attenuate Metabolic Changes Induced by High-Fat Diet
Saturated fats in the diet can cause deleterious effects on health, which could be minimized through physical activity and the consumtion of functional foods with medicinal qualities.[7:1]
Grape juice can help lower lipid peroxidation (fat oxidation), interleukin-6 (IL6) concentration and systolic blood pressure (SBP) while also positivley increasing healthy gut microbiota.[7:2]
The consumption of grape juice, together with physical exercise, may be able to promote beneficial metabolic changes even in the presence of a traditional High Fat Diet.[7:3]
Disease / Symptom Treatment
Resveratrol can help prevent cellular and behavioral sensory alterations to the brain during fetal development.
Resveratrol induces apoptosis associated with mitochondrial dysfunction in bladder carcinoma cells.
Resveratrol can inhibit the occurrence and development of cervical cancer.
Resveratrol induces apoptosis in human gastric carcinoma.[2:1]
Resveratrol induces apoptosis in pancreatic cancer cells.
Resveratrol enhances radiation sensitivity in prostate cancer by inhibiting cell proliferation and promoting cell senescence and apoptosis.
Resveratrol may be promising for the treatment of damage in the enteric nervous system caused by diabetes (the enteric nervous system is embedded in the lining of the gastrointestinal system, beginning in the esophagus and extending down to the anus).[6:2]
Resveratrol prevents microbial imbalance, impaired microbiota
Resveratrol potentially inhibits several key steps in the atherogenic process and has a protective effect on cardiovascular disease.
Resveratrol can reduce renal (kidney) oxidative stress, activate nutrient-sensing signals, modulate gut microbiota, and prevent hypertension.[10:1]
- Resveratrol improves of proteostasis (prevents degradation and misfolding of proteins in the brain).[1:1]
- Induces neuroprotection against amyloid and tau (neuro-fibrillary tangles) pathologies.[1:2]
- Promotes brain resilience and defense against neurodegeneration caused by the accumulation of aberrant proteins.
- Resveratrol administration induced complete protection against memory loss and brain pathology in mice with Alzheimer’s, and also induced cognitive enhancement in healthy mice.[10:2]
Resveratrol for Alzheimer’s may prevent neuronal death, stop amyloid deposition, and promote blood brain barrier inegrity.[3:2]
Resveratrol treatment has been shown to preserve the integrity of the blood-brain barrier (BBB) in Alzheimer’s Disease (AD) patients. Resveratrol also induced adaptive immune responses that promoted brain resilience to amyloid deposition. Resveratrol may slow cognitive decline in AD, and may arrest neuronal death. Resveratrol may seal off a leaky blood brain barrier and contribute to cognitive and functional improvement.[3:3]
Resveratrol administration promotes complete protection against memory loss.[1:3]
Nicotinamide adenine dinucleotide (NAD+)
Cell Protection (Helps prevent DNA damage)
Resveratrol can significantly potentiate the cell protection and rescue effects of Nicotinamide adenine dinucleotide (NAD+).
Resveratrol has been independently shown to significantly protect cells from DNA-damaging agents and induced cell death.[11:1]
The NAD+ precursors Nicotinic acid and Nicotinamide, when administered with Resveratrol significantly improved cell protection and rescue effects, plausibly due to increased intracellular NAD+ levels.[11:2]
Title: Resveratrol induced apoptosis in human gastric carcinoma SGC‐7901 cells via activation of mitochondrial pathway
Publication: Asia-Pacific Journal of Clinical Oncology
Date: January 2018
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Title: The effects of resveratrol and exercise on age and gender-dependent alterations of vascular functions and biomarkers
Publication: Experimental Gerontology
Date: 13 June 2018
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Title: Resveratrol: Mechanistic and therapeutic perspectives in pulmonary arterial hypertension
Publication: Pharmacological Research
Date: January 2021
Title: Resveratrol promotes neuroprotection and attenuates oxidative and nitrosative stress in the small intestine in diabetic rats
Publication: Biomedicine & Pharmacotherapy
Date: 12 June 2018
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Title: Beverages Rich in Resveratrol and Physical Activity Attenuate Metabolic Changes Induced by High-Fat Diet
Publication: Journal of the American College of Nutrition
Date: May 2020
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Title: Resveratrol Prevents Cellular and Behavioral Sensory Alterations in the Animal Model of Autism Induced by Valproic Acid
Publication: Frontiers in Synaptic Neuroscience
Date: May 22 2018
Title: Resveratrol significantly inhibits the occurrence and development of cervical cancer by regulating phospholipid scramblase 1
Publication: Journal of Cellular Biochemistry
Date: October 2018
Title: Resveratrol Prevents the Development of Hypertension Programmed by Maternal Plus Post-Weaning High-Fructose Consumption Through Modulation of Oxidative Stress, Nutrient-Sensing Signals, and Gut Microbiota
Publication: Molecular Nutrition & Food Research
Date: April 30 2018
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Title: Resveratrol and Quercetin Potentiate the Cell Protection and Rescue Effects of NAD+ Precursors in HEK293 Cells Challenged by DNA Damaging Agent, N-Methyl-N′-nitro-N-nitrosoguanidine
Publication: Sage Journals: Natural Product Communications
Date: September 24, 2021
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